The University of Central Oklahoma College of Mathematics and Science provides interdisciplinary research opportunities to both faculty and students through its four Research Centers:
- Center for Interdisciplinary Biomedical Education and Research (CIBER)
- Center for Wildlife Forensics and Conservation Studies (CFACS)
- Center for Research and Education in Interdisciplinary Computation (CREIC)
- Center for Undergraduate Research and Education in Science, Technology, Engineering and Mathematics (CURE-STEM).